CECL3.7 H2O CATALYZED FRIEDLANDER SYNTHESIS OF QUINOLINES UNDER SOLVENT-FREE CONDITIONS

The Friedlander condensation of 2-aminobenzaldehyde 1 with various carbonyl compounds containing α-methylene group 2 in the presence catalytic amount reusable catalyst CeCl3. 7H2O solvent-free grinding conditions at RT furnished corresponding quinolines 3 (Scheme I). development new methods greater efficacy, straightforward procedures and better yields still is desirable.